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Phenobarbital Induction: The induction of enzymes by phenobarbital may well vary in price and extent in between cynomolgus monkeys and humans, which may influence drug metabolism as well as the prediction of in vivo human responses.Barbiturates may perhaps impair the mental and/or Bodily talents needed for that overall performance of doubtless dang

phenobarbital will lower the level or influence of stiripentol by influencing hepatic enzyme CYP1A2 metabolism. Steer clear of or Use Alternate Drug. If struggling to stay away from coadministration of stiripentol with solid CYP1A2 inducers, maximize stiripentol dose.Barbiturates are metabolized mainly through the hepatic microsomal enzyme techniqu